Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart Study

Status: Current

Grant Start: 06/01/2021

Grant End: 05/31/2026

American Indian adults have a high burden of psychological risk factors and related sequelae, but little is known about their relation to Alzheimer’s disease. This project aims to collect psychological risk features as well as cognitive test performance data in 3,000 aging American Indian adults, in order to: test longitudinal relationships among stress, depression, substance use, quality of life, community connectedness, and cognition, and also to establish the first normative psychometric standards specific to American Indian adults using the NIH Toolbox Cognition Battery. 


  • Missouri Breaks Industries Research Inc. (MBIRI)
  • MedStar Health Research Institute (MHRI)
  • University of Oklahoma Health Science Center (OUHSC)
  • Strong Heart Study

Funding Sponsors

  • Federal - National Institutes of Health
  • National Institute on Aging (NIA)

Principal Investigator(s)

Team Member(s)

Heath Research Initiatives

  • American Indian and Alaska Native

Focus Areas

  • Alzheimer's disease
  • Cognition
  • NIH toolbox